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Molecular Cell Biology

KMBF01

Aim

To provide basic, theoretical and practical, knowledge about the reactivity of chemical compounds and toxicity as well as to highlight the structure and function of living cells, in particular the microorganisms.

Contents

The course introduces the student to the fascinating world of living cells, in particular bacteria, their genetics and physiology. The course covers enzymatic catalysis, genome of cells, cellular transport mechanisms and techniques to detect, quantify, identify and cultivate different types of microorganisms. In addition, cellular energy metabolism is covered in order to give a deeper understanding of biogeochemical cycles. In connection to energy metabolism aspects of respiration and photosynthesis are exposed.

The laboratory exercises illustrate theoretical aspects of the course such as the reactivity of chemical compounds and toxicity, purification and characterisation of enzymes, and how microorganisms may adapt to new environments through genetic exchange. The diversity of microorganisms and functionality are illustrated by studying the morphology, physiology, and growth behaviour. The genetic expression and regulation is exemplified by determining the physiological adaptation of bacteria under different cultivation conditions. The influences of cytotoxic and antimicrobial compounds are studied on eukaryotic cells as well as on bacteria.

The chemical basis for how health-damaging and environmentally hazardous compounds are absorbed and metabolized by organisms and the mechanisms behind their effects are discussed thoroughly. Emphasis is put on relationships between structure, chemical properties, and biological effects.

Contact and other information

Course coordinator: Docent Lei Ye, lei.ye@tbiokem.lth.se
Course coordinator: Docent Ed van Niel, ed.van_niel@tmb.lth.se
Course coordinator: Baozhong Zhang, baozhong.zhang@chem.lu.se

Link to Course Syllabus

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